FREDERICK M. ALLEN, M.D.
Completion of the desired range of experiments was prevented by circumstances. The material used was the regular preparation of protamine zinc insulin as supplied by Eli Lilly & Co. for clinical use. The results, though fragmentary, establish several new facts, as follows.
These observations were limited to rats. As mentioned in the previous paper, it has never been possible to produce extreme obesity in adult animals of any species with regular insulin. MacKay and Callaway 1 have recently reported the interesting discovery that this can be accomplished in rats with doses of about eight
ALLEN FM. TOLERANCE AND TOXICITY OF INSULIN: III. PROTAMINE AND ZINC COMPOUNDS1. Ann Intern Med. ;12:1870–1885. doi: 10.7326/0003-4819-12-11-1870
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Published: Ann Intern Med. 1939;12(11):1870-1885.
Cardiology, Coronary Risk Factors, Diabetes, Emergency Medicine, Endocrine and Metabolism.
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