Until 1932, investigators of diseases of the pancreas used the concentration of that fat-splitting enzyme in the serum which is capable of splitting simple esters (esterase) in the diagnosis of pancreatic disease; but the results were too variable to be of great value. In 1932, Cherry and Crandall1 reexamined the problem of fat-splitting enzymes in the serum, finding that the activity of the esterase as measured by hydrolysis of ethyl butyrate or tributyrin was affected in one of three ways: it was increased, decreased, or was not changed following experimental ligation of the pancreatic duct of dogs. They therefore concluded
SERUM LIPASE IN THE DIAGNOSIS OF THE DISEASES OF THE PANCREAS. Ann Intern Med. ;12:1896–1899. doi: 10.7326/0003-4819-12-11-1896
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Published: Ann Intern Med. 1939;12(11):1896-1899.
Gastroenterology/Hepatology, Pancreatic Disease.
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