MANDRED W. COMFORT, M.D., F.A.C.P.; CLARENCE W. ERICKSON, M.D.
Ergot preparations have enjoyed a time-honored place in obstetrical practice. In properly standardized dosage they have come to be accepted as useful oxytocics when administered after expression of the placenta; they promote uterine involution and prevent postpartum bleeding and puerperal sepsis. Since isolation of the crystalline alkaloid, ergotamine, described by Spiro and Stoll1 in 1921, numerous clinical entities have been treated by the specific ergot alkaloids. At one time in the past decade, approximately 80 medical disorders of one kind or another were enthusiastically treated with ergotamine tartrate. Peptic ulcer, migraine, pruritus, diabetes mellitus and insipidus, hyperthyroidism, glaucoma, various hemorrhagic
COMFORT MW, ERICKSON CW. UNTOWARD EFFECTS FROM THE USE OF ERGOT AND ERGOTAMINE TARTRATE1. Ann Intern Med. ;13:46–60. doi: 10.7326/0003-4819-13-1-46
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Published: Ann Intern Med. 1939;13(1):46-60.
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