I. M. RABINOWITCH, F.A.C.P.
Protamine zinc insulin is now a definitely established therapeutic agent for the treatment of diabetes mellitus. Judging from the literature, most of the difficulties which were met with, following our first reports1, 2, 3 of the product now in general use 2 appear to have been overcome. Theoretically, protamine zinc insulin appeared to be. contraindicated in conditions for which quick action is necessary, though this also was contrary to our experiences. Coma is an example. Because of its slow action in ordinary amounts, it was repeatedly stated in the literature that protamine zinc insulin is contraindicated in coma. Actually, as
RABINOWITCH IM. THE SIGNIFICANCE OF POST-PRANDIAL GLYCOSURIA IN THE TREATMENT OF DIABETES MELLITUS WITH PROTAMINE ZINC INSULIN1. Ann Intern Med. 1939;13:385–393. doi: 10.7326/0003-4819-13-3-385
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Published: Ann Intern Med. 1939;13(3):385-393.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Nephrology.
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