MARSHALL G. HALL, M.D.; ROBERT C. DARLING, M.D.; F. H. L. TAYLOR, PH.D.
In normal healthy individuals the blood serum or plasma level and the urinary excretion of vitamin C are dependent largely upon the dietary intake of the vitamin.1, 2, 3, 4 It has been shown by van Eckelen5 and Heinemann6 that normal adults have a daily requirement of 60 mg. of the vitamin.
The presence of infection is known to increase the requirements for vitamin C.7 In patients suffering with various forms of infection the level of vitamin C in the blood plasma or serum may be reduced to the level found in patients with scurvy.7 Under these circumstances the amount
MARSHALL G. HALL, ROBERT C. DARLING, F. H. L. TAYLOR. THE VITAMIN C REQUIREMENT IN RHEUMATOID ARTHRITIS(THE VITAMIN C REQUIREMENT IN RHEUMATOID ARTHRITIS*). Ann Intern Med. 1939;13:415–423. doi: 10.7326/0003-4819-13-3-415
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Published: Ann Intern Med. 1939;13(3):415-423.
Rheumatoid Arthritis, Rheumatology.
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