PERRIN H. LONG, M.D.; W. BARRY WOOD JR., M.D.
The rational utilization of any promising compound in the field of clinical chemotherapy is dependent upon a knowledge of its absorption by, distribution in, and excretion from the body. Early in the course of our studies upon sulfapyridine, we1 noted that the drug was not readily soluble, and in comparison with sulfanilamide, poorly absorbed, when it was administered to animals by the oral route. While increasing doses gave blood levels of increasing amounts, these concentrations were not at all proportional to the dose, and certain individual animals showed marked variations from time to time in their ability to absorb the
LONG PH, WOOD WB. OBSERVATIONS UPON THE EXPERIMENTAL AND CLINICAL USE OF SULFAPYRIDINE. II. THE TREATMENT OF PNEUMOCOCCAL PNEUMONIA WITH SULFAPYRIDINE (OBSERVATIONS UPON THE EXPERIMENTAL AND CLINICAL USE OF SULFAPYRIDINE. II. THE TREATMENT OF PNEUMOCOCCAL PNEUMONIA WITH SULFAPYRIDINE *). Ann Intern Med. 1939;13:487–512. doi: 10.7326/0003-4819-13-3-487
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Published: Ann Intern Med. 1939;13(3):487-512.
Infectious Disease, Pneumonia, Pulmonary/Critical Care.
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