G. W. THORN
Thomas Addison's description (1855) of a clinical syndrome (morbus addisonii) which resulted from destruction of the adrenal glands first called attention to the vital function of these organs. Shortly thereafter Brown-Sequard (1856) demonstrated conclusively that complete removal of both adrenals was followed promptly by death of the experimental animal. The studies of Vulpian, Oliver, Schaeffer, Abel, Takamine and Aldrich ultimately resulted in the isolation of epinephrin from the adrenal medulla. However, treatment with epinephrin was ineffective in controlling the signs and symptoms of adrenal insufficiency. It was also observed experimentally that the complete removal of one adrenal, accompanied by destruction
THORN GW. PROGRESS IN ADRENAL CORTICAL HORMONE THERAPY. Ann Intern Med. ;13:552–555. doi: 10.7326/0003-4819-13-3-552
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Published: Ann Intern Med. 1939;13(3):552-555.
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