NELSON W. BARKER, M.D., F.A.C.P.
The pathogenesis of arteriosclerosis has been the subject of controversy for many years. Among certain investigators there has arisen the concept that the development of atheroma is associated with disturbances of lipoid metabolism. The chief reasons for this can be summarized as follows: Pathologists from the time of Virchow6 have noted the presence of comparatively large amounts of both cholesterol and neutral fat in atheromatous formations even in their earliest stages of development. More recently Leary11, 12 has concluded that the development of the entire picture of arteriosclerosis is associated with these lipoid deposits and subsequent reaction of the vascular
BARKER NW. THE PLASMA LIPOIDS IN ARTERIOSCLEROSIS OBLITERANS1. Ann Intern Med. ;13:685–692. doi: 10.7326/0003-4819-13-4-685
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Published: Ann Intern Med. 1939;13(4):685-692.
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