BERNARD S. EPSTEIN, M.D.; ALEXANDER GERBER, M.D.
The cardiovascular complications of inadequate vitamin consumption have been traced to vitamin B1 deficiency. The specificity and cure of the cardiac manifestations of this avitaminosis recently were reaffirmed by Hashimoto,1 who reported a case in which dramatic recovery followed the intravenous administration of minute quantities of purified and concentrated vitamin B1.
The condition may manifest itself in a 'dry' type, characterized by muscle wasting and peripheral neuritis, or a 'wet' type in which generalized edema and cardiovascular disturbances predominate. The combination of an acute form of one type with a mild form of the other is uncommon, and likewise the
EPSTEIN BS, GERBER A. BERI-BERI; SEVERE MANIFESTATIONS OF BOTH THE 'WET' AND 'DRY' FORMS IN THE SAME PATIENT; RECOVERY FOLLOWING TREATMENT1. Ann Intern Med. ;13:728–737. doi: 10.7326/0003-4819-13-4-728
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Published: Ann Intern Med. 1939;13(4):728-737.
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