O. P. KIMBALL, M.D., F.A.C.P.; T. N. HORAN, M.D., F.A.C.P.
The drug diphenyl-hydantoin has been known for several years but it was so nearly insoluble that it was considered practically useless. In 1937 the sodium salt of this compound was prepared in the Parke-Davis Laboratories and this drug (sodium-diphenyl-hydantoinate) was studied for anticonvulsant properties by Merritt and Putnum of Boston.1 Because of its promise as an anticonvulsant, thorough pharmacological studies were made. Animal experimentation showed it to be practically non-toxic and to have little or no hypnotic effect. The method of excretion and end products could not be determined. From observation it was believed that there was no tendency toward
KIMBALL OP, HORAN TN. THE USE OF DILATIN IN THE TREATMENT OF EPILEPSY1. Ann Intern Med. 1939;13:787–793. doi: 10.7326/0003-4819-13-5-787
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Published: Ann Intern Med. 1939;13(5):787-793.
Neurology, Seizure Disorders.
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