ALEXANDER BRUNSCHWIG, M.D.; T. HOWARD CLARKE, M.D.
The high incidence of hyposecretion of the stomach, hypochlorhydria and achlorhydria accompanying gastric cancer has long been known. The exact incidence varies in different statistics, and will also vary of course with the age of any group of patients since the frequency of achlorhydria unaccompanied by other apparent abnormalities increases with age.
In a group of 70 patients at the University of Chicago Clinics in whom carcinoma of the stomach was verified at operation or necropsy and who were for the most part in middle or advanced age, 38 (59 per cent) exhibited achlorhydria, 11 (16 per cent) exhibited hypochlorhydria
BRUNSCHWIG A, CLARKE TH. HISTOLOGIC STRUCTURE OF CARCINOMAS OF THE STOMACH AND QUALITY OF GASTRIC SECRETIONS1. Ann Intern Med. ;13:1001–1004. doi: 10.7326/0003-4819-13-6-1001
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Published: Ann Intern Med. 1939;13(6):1001-1004.
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