R. A. BUSSABARGER; A. C. IVY, F.A.C.P.; H. S. WIGODSKY; F. D. GUNN
The etiology of pernicious anemia is an unsolved problem. Until this disease can be produced experimentally the etiology will probably remain uncertain.
The almost constant presence of achylia gastrica in this disease and the series of experiments by Castle and his associates6 suggest that a gastric disorder plays a primary rôle in the pathogenesis of pernicious anemia. Complete removal of the stomach from animals should provide experimental evidence relating to such an hypothesis.
The entire stomach of various types of adult animals [dog1, 4, 7, 9, 16, 20, 25, 29a, 34, 37, 43; cat5; rat3b, 21; pig2a, 2b, 3c, 13,
BUSSABARGER RA, IVY AC, WIGODSKY HS, GUNN FD. THE EFFECT OF GASTRECTOMY ON THE MONKEY1. Ann Intern Med. ;13:1028–1041. doi: 10.7326/0003-4819-13-6-1028
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Published: Ann Intern Med. 1939;13(6):1028-1041.
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