E. MESSINGER, A.B., M.D.; N. MOROS, B.S., M.D.
Since von Meduna1 first reported his success in the treatment of schizophrenia by the induction of convulsions with metrazol, his method has enjoyed considerable popularity, and has been employed in many hundreds of cases.
His method consists essentially in the repeated (three times weekly) induction of severe epileptiform convulsions of a specific type by the rapid intravenous injection of large doses of metrazol (pentamethylenetetrazol, formerly known as cardiazol), in a 10 per cent aqueous solution. The initial dose usually employed is 3 to 5 c.c. and it is usually increased progressively so that convulsions are regularly obtained—until a course of
MESSINGER E, MOROS N. CARDIOVASCULAR EFFECTS OF LARGE DOSES OF METRAZOL AS EMPLOYED IN THE TREATMENT OF SCHIZOPHRENIA1. Ann Intern Med. ;13:1184–1204. doi: 10.7326/0003-4819-13-7-1184
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Published: Ann Intern Med. 1940;13(7):1184-1204.
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