SLOAN J. WILSON, M.D.; CHARLES A. DOAN, M.D., F.A.C.P.
Artificially induced fever has attained a definite place among modern therapeutic procedures. Hyperpyrexia, however, is attended by actual, as well as by potential dangers, as is usually the case with any powerful therapeutic agent. Tissue injury from prolonged or excessive exposure to heat has long been recognized. Two of the most constant pathologic findings under such circumstances have been acute liver damage and hemorrhage. In replies to a questionnaire regarding fever therapy, which was sent to physicians by the Council on Physical Therapy, "several reported instances of cerebral hemorrhage."1 Five fatalities have been cited by Hartman and Major2, 3 and
WILSON SJ, DOAN CA. THE PATHOGENESIS OF HEMORRHAGE IN ARTIFICIALLY INDUCED FEVER1. Ann Intern Med. ;13:1214–1229. doi: 10.7326/0003-4819-13-7-1214
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Published: Ann Intern Med. 1940;13(7):1214-1229.
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