TOM D. SPIES, M.D., F.A.C.P.; WILLIAM B. BEAN, M.D.; RICHARD W. VILTER, M.D.
From our studies of a large series of persons with mixed vitamin deficiency, we reported recently1, 2, 3 that the diagnostic manifestations of pellagra, beriberi, riboflavin deficiency, vitamin A deficiency and vitamin B6 deficiency respond to the administration of large amounts of synthetic nicotinic acid, thiamin hydrochloride, riboflavin, oleum percomorphum, and synthetic vitamin B6 respectively. Each of these active chemical substances, in addition to its specific action for the relief of certain characteristic symptoms, promotes a general sense of well-being in these persons. Following the administration of crystalline vitamin supplements to their inadequate diets, the patients often became strong enough
SPIES TD, BEAN WB, VILTER RW. ADENYLIC ACID IN HUMAN NUTRITION1. Ann Intern Med. ;13:1616–1618. doi: 10.7326/0003-4819-13-9-1616
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Published: Ann Intern Med. 1940;13(9):1616-1618.
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