EUGENE R. MARZULLO, M.D., F.A.C.P.
Uremia is a toxic state associated with an abnormal accumulation of nitrogen bodies in the blood. It is characterized clinically by anorexia, nausea, vomiting, weakness, restlessness, headache, drowsiness or coma. The exact nature of the toxemia of uremia is not known, although such substances as urea, uric acid, creatinine, phosphates, sulphates are present in the blood in excessive amounts. It was Bright himself who first designated as uremia the group of symptoms characteristic of renal failure, because he thought these symptoms were due to a retention of urea in the blood. Bright regarded urea as a highly toxic substance but
MARZULLO ER. CLINICAL STUDIES IN RENAL DISEASE. III. ACIDOSIS IN CHRONIC GLOMERULONEPHRITIS1. Ann Intern Med. ;13:1638–1643. doi: 10.7326/0003-4819-13-9-1638
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Published: Ann Intern Med. 1940;13(9):1638-1643.
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