RENÉ J. DUBOS
Organic matter does not accumulate in nature; it rapidly becomes the prey of countless species of microörganisms which break it down, stepwise, to carbon dioxide, water, ammonia, and mineral salts. It is known moreover that, under natural conditions, each one of these microbial species is adapted to the performance of a limited, well-defined biochemical task. It seems certain, therefore, that one can find in nature microörganisms selectively adapted to the decomposition of almost every conceivable type of organic compound.9
Like all living cells, microörganisms carry out their biochemical function through the agency of enzymes and other catalysts. In many cases
DUBOS RJ. THE EFFECT OF SPECIFIC AGENTS EXTRACTED FROM SOIL MICROÖRGANISMS UPON EXPERIMENTAL BACTERIAL INFECTIONS1. Ann Intern Med. ;13:2025–2037. doi: 10.7326/0003-4819-13-11-2025
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Published: Ann Intern Med. 1940;13(11):2025-2037.
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