ROBERT H. WILLIAMS, M.D.; WILLIAM J. CROMARTIE, M.D.
The fungus infection now known as histoplasmosis, and its causative agent, the Histoplasma capsulatum, were first described by Darling in 1906 and 1908.1, 2 He reported three cases. Since then, single cases of histoplasmosis have been reported by Riley and Watson,3 Phelps and Mallory,4 Crumrine and Kessell,5 and Dodd and Tompkins.6
The disease is manifested clinically by moderate fever, emaciation, splenomegaly, hepatomegaly, enlargement of lymph nodes, leukopenia and slight anemia. In only one of the seven cases recorded was an accurate diagnosis made antemortem. Dodd and Tompkins recognized the parasite in the large mononuclear cells (monocytes) of the blood of
WILLIAMS RH, CROMARTIE WJ. HISTOPLASMOSIS: REPORT OF A CASE1. Ann Intern Med. ;13:2166–2171. doi: 10.7326/0003-4819-13-11-2166
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Published: Ann Intern Med. 1940;13(11):2166-2171.
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