Since effective antipneumococcal sera first became available for the treatment of acute lobar pneumonia the need of some precise method for determining the quantity of serum required has been evident. Attempts have been made to estimate this by considering such factors as the day of the disease on which treatment is started, the extent of the lung tissue affected, the presence or absence of bacteremia and the apparent degree of intoxication, as well as the clinical response to treatment. Although these points are of considerable assistance in the absence of more precise standards, experience soon showed that they are not
C. P. CONTROL OF THE DOSAGE OF ANTIPNEUMOCOCCAL SERUM IN THE TREATMENT OF PNEUMONIA. Ann Intern Med. ;13:2178–2180. doi: 10.7326/0003-4819-13-11-2178
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Published: Ann Intern Med. 1940;13(11):2178-2180.
Infectious Disease, Pneumonia, Pulmonary/Critical Care.
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