LOUIS E. PRICKMAN, M.D., F.A.C.P.; HAROLD I. LILLIE, M.D.; GRACE M. ROTH, PH.D.; RALPH G. FLEMING, M.D.
For many years it has been suspected that histamine has a rôle in the allergic reaction. If this is true, a substance having the ability to detoxify histamine would seem to have useful therapeutic possibilities in the treatment of allergic conditions. An intestinal extract2 said to have such detoxifying properties against histamine, has been supplied to us for therapeutic trial in the treatment of allergic conditions and this paper deals with our preliminary clinical observations in the use of this product.
Only a few of many important experimental and clinical observations on the rôle of histamine in relation to allergy
PRICKMAN LE, LILLIE HI, ROTH GM, FLEMING RG. RESULTS OF THE USE OF EXTRACT OF THE INTESTINAL MUCOSA IN THE TREATMENT OF VASOMOTOR RHINITIS1. Ann Intern Med. ;13:2235–2240. doi: 10.7326/0003-4819-13-12-2235
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Published: Ann Intern Med. 1940;13(12):2235-2240.
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