A. C. CURTIS, M.D., F.A.C.P.; H. M. POLLARD, M.D., F.A.C.P.
In 1924 Felty1 described a syndrome occurring in five cases characterized by chronic rheumatoid arthritis, splenomegaly, and leukopenia. The syndrome occurred in individuals of middle age; all patients gave a history of marked loss of weight and all were undernourished; the arthritic process was distinctly chronic with an average duration of four and one-half years; the onset was either acute or gradual; and in the extremities occurred a generalized articular aching, which was mild but persistent, and accentuated by an occasional acute exacerbation.
In two of the cases the spleens were palpable just below the costal margins, in two others
CURTIS AC, POLLARD HM. FELTY'S SYNDROME; ITS SEVERAL FEATURES, INCLUDING TISSUE CHANGES, COMPARED WITH OTHER FORMS OF RHEUMATOID ARTHRITIS1. Ann Intern Med. ;13:2265–2284. doi: 10.7326/0003-4819-13-12-2265
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Published: Ann Intern Med. 1940;13(12):2265-2284.
Rheumatoid Arthritis, Rheumatology.
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