ISRAEL KOPP, M.D.
The literature now contains many case reports of agranulocytosis since its first description by Schultz in 1922.1 Various hypotheses as to its etiology have been offered, and a number of drugs, nearly all containing the benzene ring, have been implicated.2, 3, 4
Agranulocytosis has been defined as a disease in which essentially there is a marked diminution or total absence of the granulocytes of the peripheral blood, which is followed by a loss of cellular resistance as shown by infectious processes of various types.4 Various other descriptive terms have been given to this syndrome, such as agranulocytic angina, primary granulocytopenia
KOPP I. CHRONIC LEUKOPENIA WITH FATAL TERMINATION DUE TO AGRANULOCYTIC ANGINA; CASE REPORT1. Ann Intern Med. ;13:2347–2354. doi: 10.7326/0003-4819-13-12-2347
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Published: Ann Intern Med. 1940;13(12):2347-2354.
Cardiology, Coronary Heart Disease.
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