R. C. PAGE, M.D.; H. K. RUSSELL, M.D.; R. L. ROSENTHAL, M.D.
The present conception of hemophilia1 is that it is a constitutional disease characterized by prolonged hemorrhage, due to increased coagulation time. There is an inherited, sex-linked defect in the clotting mechanism. The typical finding is an increased coagulation time, which apparently results from a deficient supply of thromboplastin, which is in turn due to an abnormal resistance of the platelets to disintegration.
Quick2 states that if thromboplastin is added, hemophilic blood will coagulate as rapidly as normal blood. This indicates that a deficiency of thromboplastin is the probable cause of the defective clotting, and that it is probably the slow
PAGE RC, RUSSELL HK, ROSENTHAL RL. EFFECT OF OXALIC ACID INTRAVENOUSLY ON BLOOD-COAGULATION TIME IN THREE HEMOPHILIACS1. Ann Intern Med. 1940;14:78–86. doi: 10.7326/0003-4819-14-1-78
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Published: Ann Intern Med. 1940;14(1):78-86.
Hematology/Oncology, Hospital Medicine.
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