MAXWELL SPRING, M.D.; ISIDOR BERNSTEIN, M.D.
In 1937 Harvey and Janeway1 first described acute hemolytic anemia as a toxic manifestation of sulfanilamide therapy. They presented three cases in adults. Shortly thereafter Kohn2 and Willis3 each presented a case in an infant. Wood4 studied 522 patients, 144 children and 378 adults, receiving sulfanilamide and found that 21 developed acute anemia. Of these, 12 or 8.3 per cent were children, and nine or 2.4 per cent were adults. Long, Bliss and Feinstone5 in their study of 307 adults and 101 children found the incidence 2.9 per cent and 8.9 per cent respectively. In 1938 Bannick, Brown and Foster6
SPRING M, BERNSTEIN I. THE COEXISTENCE OF TOXIC HEPATITIS, ACUTE HEMOLYTIC ANEMIA AND RENAL DAMAGE FOLLOWING SULFANILAMIDE THERAPY; REPORT OF TWO CASES1. Ann Intern Med. ;14:153–164. doi: 10.7326/0003-4819-14-1-153
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Published: Ann Intern Med. 1940;14(1):153-164.
Emergency Medicine, Gastroenterology/Hepatology, Hematology/Oncology, Liver Disease, Nephrology.
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