GORDON B. MYERS, M.D., F.A.C.P.; JACK ROM, M.D.
While acute hemolytic anemia is a fairly common complication of sulfanilamide therapy and has been carefully studied by numerous workers,1, 2, 3 massive hemoglobinuria is relatively rare and has received little attention. Among 21 cases of sulfanilamide hemolytic anemia reported by Wood,3 free hemoglobin was found in the urine in only one instance. Bohlman,4 in discussing the toxic manifestations of sulfanilamide, referred to a personal communication from Janeway, who had had one case with hemolytic anemia, hemoglobinuria and uremia. In five other cases of sulfanilamide hemolytic anemia, reported in three different papers,5, 6, 7 hemoglobinuria was noted as an incidental
MYERS GB, ROM J. ACUTE HEMOLYTIC ANEMIA, HEMOGLOBINURIA AND UREMIA FOLLOWING SULFANILAMIDE1. Ann Intern Med. ;14:164–168. doi: 10.7326/0003-4819-14-1-164
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Published: Ann Intern Med. 1940;14(1):164-168.
Hematology/Oncology, Nephrology, Red Cell Disorders, Urological Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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