JOSEPH M. HILL, M.D.; DAVID C. PFEIFFER, M.E.
A practical and inexpensive desiccation process is vital to the development of the widespread use of plasma and serum (ordinary or convalescent) because it solves two main problems in this field. First, storage difficulties practically cease to exist. While it is true that liquid serum may be stored, even without refrigeration as emphasized recently by Levinson,1 there is no margin of safety. Contamination with but one bacterium could quickly spoil this excellent culture medium if stored without refrigeration. Also at room temperatures, the antibodies, prothrombin and other valuable biological properties rapidly deteriorate. By contrast, serum stored in the dry so-called
HILL JM, PFEIFFER DC. A NEW AND ECONOMICAL DESICCATING PROCESS PARTICULARLY SUITABLE FOR THE PREPARATION OF CONCENTRATED PLASMA OR SERUM FOR INTRAVENOUS USE: THE ADTEVAC PROCESS1. Ann Intern Med. 1940;14:201–214. doi: 10.7326/0003-4819-14-2-201
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Published: Ann Intern Med. 1940;14(2):201-214.
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