SAMUEL MORRISON, M.D., F.A.C.P.
In a paper on the mechanism of therapy in pernicious anemia, Greenspon1 suggested that an "extrinsic factor" as conceived by Castle was unnecessary and that an antianemic principle protected from the inactivating effect of pepsin, such as beef (or other source of "extrinsic factor") was solely essential. This suggestion coincided with our belief that antipernicious anemia potency may be attributed to the fundus as well as to other portions of the stomach, and that this potency is ordinarily neutralized by the action of pepsin, a product primarily of the fundus. Greenspon's contention if confirmed will strongly support our belief.
MORRISON S. STUDIES IN PERNICIOUS ANEMIA: AN INQUIRY INTO THE RÔLE OF PEPSIN1. Ann Intern Med. ;14:242–254. doi: 10.7326/0003-4819-14-2-242
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Published: Ann Intern Med. 1940;14(2):242-254.
Hematology/Oncology, Red Cell Disorders.
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