WILLIAM D. STROUD, M.D., F.A.C.P.; PAUL H. TWADDLE, M.D.
There is considerable evidence in the literature1, 2 that Coramine (Ciba), a 25 per cent aqueous solution of the diethylamide of pyridine beta carboxylic acid, has been established as a valuable agent in the treatment of cerebral and respiratory depression due to poisoning by the barbiturates, avertin, alcohol, opiates, etc. There is little conclusive evidence concerning its action on the circulatory system2, 3 or on the respiratory distress of heart disease, although there appears to be a definite impression that benefit does follow its use. Objective evidence to explain the symptomatic response has not been striking.
A number of independent
STROUD WD, TWADDLE PH. OBSERVATIONS UPON THE EFFECT OF CORAMINE IN CERTAIN CARDIAC STATES1. Ann Intern Med. 1940;14:361–377. doi: 10.7326/0003-4819-14-3-361
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Published: Ann Intern Med. 1940;14(3):361-377.
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