MARTIN CLYMAN, M.D.
An anticatalase activity of sulfanilamide in concentrations in vitro equivalent to those found in vivo during sulfanilamide therapy, was first observed by Main, Shinn and Mellon.13 In extending these observations Locke, Main and Mellon11 have concluded that hydrogen peroxide, which accumulates due to the diminished catalase activity, and not the sulfanilamide per se, is the active agent in combating bacterial infections. Hydrogen peroxide in pneumococcus cultures (Type 1, 18 hr. growth) was estimated by Shinn, Main and Mellon25 who were able to detect concentrations as small as 0.0003 per cent. Retardation of growth of cultures containing sulfanilamide was accompanied by
CLYMAN M. THE ANTICATALASE ACTIVITY OF SULFANILAMIDE AND SULFAPYRIDINE IN VIVO1. Ann Intern Med. ;14:406–414. doi: 10.7326/0003-4819-14-3-406
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Published: Ann Intern Med. 1940;14(3):406-414.
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