JOHN MARTIN ASKEY, F.A.C.P.
The diagnosis of Addisonian pernicious anemia ordinarily is made over a year after symptoms have been definitely established.1 About 75 per cent of patients with this disease have involvement of the nervous system,2, 3 and this condition is often recognized too late to prevent partially disabling nervous system lesions. The deaths attributable to pernicious anemia are due largely to complications of these lesions. Treatment may prevent further progress but cannot correct irreparable spinal cord damage.
The challenge for the future must be to diagnose pernicious anemia before the appearance of blood and nervous system changes. This will inaugurate an era
ASKEY JM. PREVENTION OF PERNICIOUS ANEMIA: RECOGNITION OF THE LATENT STAGE IN RELATIVES(PREVENTION OF PERNICIOUS ANEMIA: RECOGNITION OF THE LATENT STAGE IN RELATIVES*). Ann Intern Med. 1940;14:593–607. doi: 10.7326/0003-4819-14-4-593
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Published: Ann Intern Med. 1940;14(4):593-607.
Hematology/Oncology, Red Cell Disorders.
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