H. M. MARGOLIS, M.D., F.A.C.P.; V. W. EISENSTEIN, M.D.
New therapeutic agents, like new servants, are apt to present their best sides first, and only upon longer acquaintance reveal the disagreeable traits which hinder their usefulness. Despite technical refinements and improvements in the uniformity and stability of the new insulin products, which culminated in the development of protamine zinc insulin, frequent failings of the slower acting insulins have become apparent with extended experience. Briefly, these failings were manifest in diurnal glycosuria, in the necessity for supplementary injections of regular insulin, in serious, even fatal, reactions, and often, in fact, in such erratic diabetic control as to force the abandonment
MARGOLIS HM, EISENSTEIN VW. THE TREATMENT OF DIABETES MELLITUS WITH A FOUR-MEAL DIET: A MEANS OF CIRCUMVENTING CERTAIN DIFFICULTIES ARISING IN THE USE OF PROTAMINE ZINC INSULIN1. Ann Intern Med. 1940;14:667–687. doi: 10.7326/0003-4819-14-4-667
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Published: Ann Intern Med. 1940;14(4):667-687.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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