EDWIN J. KEPLER, M.D., F.A.C.P.; DONALD R. NICHOLS, M.D.; JOHN H. MILLS, M.D., F.A.C.P.
Case reports of hemochromatosis associated with regression of the secondary sexual characteristics have appeared in the literature sporadically.1, 2, 3, 4 It is not generally appreciated, however, that these findings may appear relatively early in the course of the disease and, therefore, give a clue to the diagnosis before bronzing of the skin, enlargement of the liver, and diabetes become diagnostically manifest. The two cases herein reported are illustrative. The first case was studied before we were aware of the fact that signs of hypogonadism or anterior pituitary insufficiency occurred in conjunction with hemochromatosis. As there was comparatively little pigmentation
KEPLER EJ, NICHOLS DR, MILLS JH. THE DIAGNOSTIC VALUE OF REGRESSION OF SECONDARY SEXUAL CHARACTERISTICS IN CASES OF HEMOCHROMATOSIS(THE DIAGNOSTIC VALUE OF REGRESSION OF SECONDARY SEXUAL CHARACTERISTICS IN CASES OF HEMOCHROMATOSIS*). Ann Intern Med. 1940;14:810–816. doi: 10.7326/0003-4819-14-5-810
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Published: Ann Intern Med. 1940;14(5):810-816.
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