ROBERT C. DARLING, M.D.
The finding of a severe degree of oxygen unsaturation in the arterial blood of patients with cirrhosis of the liver has been reported by Snell.1 Later, Keyes and Snell2 studied a further series with oxygen dissociation curves, and found a small but significant shift in the curve from the accepted normal value. In this second series the oxygen unsaturation of the arterial blood was less marked than in the first series. From this work it was concluded that the hemoglobin in liver disease had properties somewhat different from normal.
Since there are few objective tests for measuring the disturbances of
DARLING RC. ARTERIAL OXYGEN SATURATION IN CIRRHOSIS OF THE LIVER1. Ann Intern Med. 1940;14:898–902. doi: 10.7326/0003-4819-14-5-898
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Published: Ann Intern Med. 1940;14(5):898-902.
Gastroenterology/Hepatology, Liver Disease, Pulmonary/Critical Care.
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