A. H. FINEMAN, M.D., F.A.C.P.
Angioneurotic edema is usually regarded as a peculiar and interesting condition, appearing suddenly as a subcutaneous, localized swelling on one or more parts of the body and disappearing gradually without leaving any discernible evidence of the reaction. It was first described in detail by Quincke,1 in 1882, as "an acute circumscribed edema of the skin" to differentiate it from the wellknown superficial whealing of urticaria, and given the name angioneurotic edema by Strübing,2 three years later. It was believed by both these authors that the underlying mechanism responsible for this condition was a vasomotor disturbance of the blood vessels (angioneurosis)
FINEMAN AH. HEREDITARY ANGIONEUROTIC EDEMA1. Ann Intern Med. ;14:916–921. doi: 10.7326/0003-4819-14-5-916
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Published: Ann Intern Med. 1940;14(5):916-921.
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