FRANCIS C. LOWELL; ELIAS STRAUSS; MAXWELL FINLAND, F.A.C.P.
Strains of pneumococci have been shown to vary in their susceptibility to the action of the same sulfonamide drugs both in vitro1-4 and in therapeutic experiments in vivo.1, 5 These differences in susceptibility have been noted among strains of the same type6 and among different types.1-5 Resistance to the action of sulfapyridine has been induced in previously susceptible strains both in vitro7 and in animals experimentally infected and treated with subeffective amounts of drugs.1 In this paper is presented a study of the in vitro susceptibility to sulfapyridine, sulfathiazole and sulfamethylthiazole of pneumococci isolated from patients undergoing treatment with either
LOWELL FC, STRAUSS E, FINLAND M. OBSERVATIONS ON THE SUSCEPTIBILITY OF PNEUMOCOCCI TO SULFAPYRIDINE, SULFATHIAZOLE AND SULFAMETHYLTHIAZOLE1. Ann Intern Med. ;14:1001–1023. doi: 10.7326/0003-4819-14-6-1001
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Published: Ann Intern Med. 1940;14(6):1001-1023.
Infectious Disease, Streptococcal Infections.
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