CARL J. WIGGERS, M.D., F.A.C.P.
The reactions of the cardiovascular system in man to progressively diminishing oxygen have been repeatedly described, among others by Whitney,1 Schneider,2 Schneider and Truesdell,3 Gellhorn,4 and Armstrong.6 While there are variations assignable to individual sensitivity, speed in development of anoxia, etc., the following reactions commonly occur in standard rebreathing tests: The heart rate increases, systolic pressure rises slightly and diastolic pressure either remains stationary or changes slightly in upward or downward directions. A dynamic analysis of such data indicates that the diminishing oxygen-carrying capacity of the blood is compensated by increased circulating volume as well as
WIGGERS CJ. CARDIAC ADAPTATIONS IN ACUTE PROGRESSIVE ANOXIA1. Ann Intern Med. 1941;14:1237–1247. doi: 10.7326/0003-4819-14-7-1237
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Published: Ann Intern Med. 1941;14(7):1237-1247.
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