JESSE G. M. BULLOWA, M.D.; SAMUEL C. BUKANTZ, M.D.; PAUL F. DE GARA, M.D.
The antigen-antibody balance in pneumococcal pneumonia was first reported by Blake,1 who employed the methods of detection described by Dochez and Avery.2, 3 Blake1 studied 19 cases and demonstrated capsular polysaccharide in the blood of 11, 10 of whom died. Circulating antibody was not detected in these patients, nor in those who excreted large amounts of capsular polysaccharide in the urine. It has since been shown experimentally that capsular polysaccharide may interfere with defenses against the pneumococcus by enhancing the invasive power of pneumococci (Felton and Bailey4; A. W. Downie5), or by blocking the reaction between pneumococcal antigen and
BULLOWA JGM, BUKANTZ SC, DE GARA PF. THE BALANCE BETWEEN CAPSULAR POLYSACCHARIDE AND ANTIBODY IN RELATION TO THE PROGNOSIS AND THERAPY OF PNEUMOCOCCAL PNEUMONIA1. Ann Intern Med. ;14:1348–1359. doi: 10.7326/0003-4819-14-8-1348
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Published: Ann Intern Med. 1941;14(8):1348-1359.
Infectious Disease, Pneumonia, Pulmonary/Critical Care, Streptococcal Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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