The demonstration by Goldblatt and his associates that injury to renal tissue produced by ischemia may result in sustained hypertension has stimulated a search for some substance to explain this activity. Some of the implications of Goldblatt's work have been discussed editorially in this journal.1 It has been shown that the pressor response is not dependent upon the nervous system. The endocrine glands apparently play only a subsidiary part. Removal of the damaged kidney, however, abolishes the hypertension if the other kidney is normal. These facts led Goldblatt to suggest that the hypertension was excited by some substance that was
C. P. HUMORAL FACTORS IN THE CONTROL OF HYPERTENSION. Ann Intern Med. ;14:1449–1451. doi: 10.7326/0003-4819-14-8-1449
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Published: Ann Intern Med. 1941;14(8):1449-1451.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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