A. M. RABINER, M.D.; HENRY JOACHIM, M.D., F.A.C.P.; I. S. FREIMAN, M.D.
In two instances we have observed following splenectomy the rapid onset of symptoms indicating hepatolenticular degeneration. In both cases the operation had been performed because of anemia and purpura associated with splenomegaly. So far as we can determine, the development of the hepatolenticular syndrome has not hitherto been reported as a sequel in the clinical course of any cases of purpura in which splenectomy has been done. These cases therefore are being presented to record this occurrence, to direct attention to a possible contra-indication for splenectomy, and as a basis for discussion of the inter-relationship that we feel exists between
RABINER AM, JOACHIM H, FREIMAN IS. HEPATO-LENTICULAR DEGENERATION (WILSON'S DISEASE) FOLLOWING SPLENECTOMY; INTER-RELATIONSHIP OF THE RETICULO-ENDOTHELIAL AND CENTRAL NERVOUS SYSTEMS1. Ann Intern Med. ;14:1781–1801. doi: 10.7326/0003-4819-14-10-1781
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Published: Ann Intern Med. 1941;14(10):1781-1801.
Encephalopathy, Gastroenterology/Hepatology, Liver Disease, Neurology.
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