E. H. RYNEARSON
During recent years there have been two advances in our knowledge of hyperinsulinism. The first is the report of additional proved cases of this interesting condition; the second is the increasing insistence that the term hyperinsulinism be reserved for those cases in which there is proof that the symptoms are caused by the excessive production of endogenous insulin. In all other cases in which hypoglycemia is a finding the condition should be diagnosed as "spontaneous hypoglycemia"
True hyperinsulinism is a rare disease. Frantz, 1 who recently reviewed the world literature, found only 96 cases in which the diagnosis had been
RYNEARSON EH. "HYPERINSULINISM" AND "SPONTANEOUS HYPOGLYCEMIA". Ann Intern Med. ;14:2157–2158. doi: 10.7326/0003-4819-14-11-2157
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Published: Ann Intern Med. 1941;14(11):2157-2158.
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