HERBERT K. ENSWORTH, M.D.; JAMES LIEBMANN, M.D.; MERTON C. LOCKHART, PH.D.; NORMAN PLUMMER, M.D.
When satisfactory oral therapy with sulfapyridine is impossible, or when it is desired rapidly to obtain high blood concentrations of the drug, parenteral administration is necessary. Sodium sulfapyridine may be used for this purpose, but may sclerose veins, or cause local necrosis from accidental extravasation. In the search for soluble forms of the drug, preparations of sulfapyridine in glucose solutions have been made. Blake and Haviland1 were able to get 2 grams of sulfapyridine into solution in a liter of fluid containing equal parts of 5 per cent glucose in distilled water and physiological saline which had been brought to
ENSWORTH HK, LIEBMANN J, LOCKHART MC, PLUMMER N. GLUCOSE-SULFAPYRIDINE; EXPERIMENTAL AND CLINICAL STUDIES1. Ann Intern Med. ;15:52–62. doi: 10.7326/0003-4819-15-1-52
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Published: Ann Intern Med. 1941;15(1):52-62.
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