SOLOMON S. RINKOFF, M.D.; MAXWELL SPRING, M.D.
The discovery of the therapeutic effectiveness of sulfanilamide and its related substances constitutes one of the greatest advances in medical therapeutics rivaling that of arsphenamine and its compounds in the treatment of lues, and that of quinine in the treatment of malaria.
The medical profession embraced these new drugs with great enthusiasm, and their use became widespread. Soon, however, reports of toxicity following the administration of these related substances appeared in the literature. Leukopenia, granulocytopenia and agranulocytosis were three of the more serious of the toxic manifestations.
Young1 in 1937, and Johnston2 in 1938 were the first to report cases
RINKOFF SS, SPRING M. TOXIC DEPRESSION OF THE MYELOID ELEMENTS FOLLOWING THERAPY WITH THE SULFONAMIDES; REPORT OF 8 CASES1. Ann Intern Med. ;15:89–107. doi: 10.7326/0003-4819-15-1-89
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Published: Ann Intern Med. 1941;15(1):89-107.
Emergency Medicine, Hospital Medicine.
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