CARL J. WIGGERS, M.D., D.SC., F.A.C.P.
The capillaries constitute the keystone of the circulation, in the sense that maintenance of an adequate capillary flow is essential for the proper exchange of respiratory gases, electrolytes and water, foodstuffs and waste products. The rate of capillary blood flow is regulated (figure 1) by the pressure in the small supplying artery (A), by the size of muscular arterioles (B), possibly by active changes in size of capillaries (C), by pressure of surrounding tissues (D), by the pressure in the small venules (E), and by the viscosity of the blood itself.
Circulatory failure, in its broadest sense, develops whenever
WIGGERS CJ. THE MECHANISMS OF PERIPHERAL CIRCULATORY FAILURE(THE MECHANISMS OF PERIPHERAL CIRCULATORY FAILURE*). Ann Intern Med. 1941;15:178–189. doi: 10.7326/0003-4819-15-2-178
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Published: Ann Intern Med. 1941;15(2):178-189.
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