JOEL J. WHITE, M.D., F.A.C.P.; JOHN V. PREVOST, M.D.
In 1886, H. A. Weil1 described a syndrome characterized by the sudden onset of prostration, fever, myalgia, jaundice, hemorrhagic tendencies and renal damage which, today, is known by his name. Inada and Ido2 discovered the spirochete in the liver of a guinea pig, inoculated with the blood of a patient suffering from the disease in 1915, and believed it to be the causative agent. They succeeded in isolating and culturing the organism and named it Spirocheta icterohemorrhagica. The following year Inada3 and a group of Japanese reported extensively on the etiology and mode of infection of this disease. In 1918,
WHITE JJ, PREVOST JV. WEIL'S DISEASE; REPORT OF THREE CASES, INCLUDING THE MORBID ANATOMY OF ONE CASE, AND A BRIEF REVIEW OF THE PERTINENT LITERATURE1. Ann Intern Med. ;15:207–225. doi: 10.7326/0003-4819-15-2-207
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Published: Ann Intern Med. 1941;15(2):207-225.
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