PAUL STARR, M.D.; HERMAN POMERENZE, M.D.
For several years attempts to suppress hyperthyroidism by various medicaments have been carried out in our clinic. The rationale of this project is furnished by the occurrence of spontaneous remissions occasionally observed in this disease and the physiological demonstration of a chalone type of mechanism in other endocrine relationships. Of the latter, pituitary suppression by estrogens, inhibition of lactation by androgens, and estrogen neutralization by progestin, may be mentioned. It would seem probable, therefore, that a physiological control of the over-active thyroid would be possible if a condition or substance acting as a chalone for the thyroid could be discovered.
STARR P, POMERENZE H. THERAPEUTIC STUDIES IN HYPERTHYROIDISM1. Ann Intern Med. ;15:226–243. doi: 10.7326/0003-4819-15-2-226
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Published: Ann Intern Med. 1941;15(2):226-243.
Endocrine and Metabolism, Thyroid Disorders.
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