ROBERT B. WRIGHT, M.D.; FRANK W. HACHTEL, M.D.
Histoplasmosis is a rare, anatomically widely disseminated, usually fatal fungus infection often characterized by fever, anemia, leukopenia and splenomegaly. The condition is caused by Histoplasma capsulatum which may be found in large numbers in the reticulo-endothelial cells and may be cultivated from the blood and other tissues. No specific therapy has been found. Mantell et al., as reported by Meleney,1 used a pentavalent antimony preparation (Neostam) possibly with some success.
The fungus, H. capsulatum, has two forms. One is yeast-like and occurs in the blood and reticulo-endothelial cells. The other, the mycelial form, is assumed when it is grown outside
WRIGHT RB, HACHTEL FW. HISTOPLASMOSIS OF DARLING; REPORT OF A CASE1. Ann Intern Med. ;15:309–319. doi: 10.7326/0003-4819-15-2-309
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Published: Ann Intern Med. 1941;15(2):309-319.
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