IRVINE H. PAGE, M.D.; O. M. HELMER, Ph.D.; K. G. KOHLSTAEDT, M.D.; G. F. KEMPF, M.D.; W. D. GAMBILL, M.D.; R. D. TAYLOR, M.D.
1. Tigerstedt and Bergmann1 demonstrated that bilateral nephrectomy increases the rise in arterial pressure occurring in anesthetized animals when extracts of kidney containing renin are injected into them. This observation was confirmed by Merrill, Williams and Harrison,2 and by Fasciolo, Houssay and Taquini3 who suggested that the increased sensitivity might be due to loss of an anti-pressor substance. Similar increase in sensitivity was observed by Page and Helmer4 when angiotonin was administered instead of renin. Angiotonin is the pressor substance resulting from interaction of renin and renin-activator.5
Nephrectomy therefore appears to remove the source of some substance which opposes the
IRVINE H. PAGE, O. M. HELMER, K. G. KOHLSTAEDT, G. F. KEMPF, W. D. GAMBILL, R. D. TAYLOR. THE BLOOD PRESSURE REDUCING PROPERTY OF EXTRACTS OF KIDNEYS IN HYPERTENSIVE PATIENTS AND ANIMALS(THE BLOOD PRESSURE REDUCING PROPERTY OF EXTRACTS OF KIDNEYS IN HYPERTENSIVE PATIENTS AND ANIMALS*). Ann Intern Med. 1941;15:347–389. doi: 10.7326/0003-4819-15-3-347
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Published: Ann Intern Med. 1941;15(3):347-389.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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