KARL SINGER, M.D.; WILLIAM DAMESHEK, M.D., F.A.C.P.
In their recent review of acute hemolytic anemia, Dameshek and Schwartz7a classify hemolytic anemia as follows:
1. Secondary to known cause (infectious, chemical, "toxic," pregnancy, etc.);
2. Symptomatic, in association with certain, usually malignant diseases, as lymphatic leukemia, Hodgkin's disease, carcinomatosis;
3. Of unknown cause, with or without hemolysins in the serum.
Symptomatic hemolytic anemia may be defined as a hemolytic syndrome often indistinguishable by hematological methods from the well-known picture of familial hemolytic jaundice, but showing a definite etiological relationship to such underlying diseases as neoplasm (teratoma, sarcoma), leukemia, and Hodgkin's disease. Frequently but not
SINGER K, DAMESHEK W. SYMPTOMATIC HEMOLYTIC ANEMIA1. Ann Intern Med. 1941;15:544–563. doi: 10.7326/0003-4819-15-3-544
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Published: Ann Intern Med. 1941;15(3):544-563.
Hematology/Oncology, Red Cell Disorders.
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