LOUIS F. FIESER, PH.D.
In the following paper such aspects of the chemistry of vitamin K are surveyed as have a direct bearing on the present and future status of the use of this vitamin factor in practical therapy. The vitamin has proved very efficacious in the limited but important field of the treatment of hypoprothrombinemia associated chiefly with obstructions of the biliary tract and with the bleeding tendency of the newborn. The possibility of the uncovering of other clinical applications should not be overlooked.
Following Dam's discovery of the existence of a dietary antihemorrhagic factor in 1929,1 a brief period of a few
FIESER LF. THE CHEMISTRY OF VITAMIN K1. Ann Intern Med. ;15:648–658. doi: 10.7326/0003-4819-15-4-648
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Published: Ann Intern Med. 1941;15(4):648-658.
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