NORBERT ENZER, M.D., F.A.C.P.; ERNST SIMONSON, M.D.; SAMUEL S. BLANKSTEIN, M.D.
Increased fatigability and sluggishness are notable complaints and symptoms of patients with endocrine disturbances, particularly in those with a reduced metabolic rate. Since increased fatigability results also from mental work and is present even under resting conditions in these patients it occurred to us that it might be due to an impairment of some functions of the central nervous system. The metabolism of nerve tissue, like that of other tissues, is influenced and regulated by hormonal factors, particularly when oxygen utilization is affected. Disturbances of nervous functions are, therefore, to be expected when there are pathological alterations in the
ENZER N, SIMONSON E, BLANKSTEIN SS. THE STATE OF SENSORY AND MOTOR CENTERS IN PATIENTS WITH HYPOTHYROIDISM1. Ann Intern Med. 1941;15:659–665. doi: 10.7326/0003-4819-15-4-659
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Published: Ann Intern Med. 1941;15(4):659-665.
Endocrine and Metabolism, Thyroid Disorders.
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